Endocrine Abstracts

Purpose: To detect persistent/recurrent disease of medullary thyroid carcinoma (MTC) after initial surgery is important. The Tumor-Node-Metastasis (TNM) staging system is useful for predicting disease-specific mortality, but it is static and does not include postoperative serum calcitonin levels. We focused on the clinical usefulness of dynamic risk stratification (DRS) using the best response to initial therapy in patients with MTC.Methods: A total of 1...

Background: Increased incidence of small differentiated thyroid cancer (DTC) has emphasized the need for risk stratification and individualized disease management for these low risk DTCs. The aim was to validate a new dynamic risk stratification (DRS) system for prediction of structural recurrent/persistent disease in patients with DTC treated without radioactive iodine (RAI) remnant ablation therapy.Methods: This historical cohort study included 357 pat...

Background: Recent studies presented that younger patients with papillary thyroid microcarcinoma (PTMC) had poorer clinical outcomes compared to older PTMC patients. The aim of this study is to investigate the impact of patient’s age on the lymph node metastasis (LNM) status of PTMC, a risk factor for recurrence and poor clinical outcome of PTMC.Methods: The study evaluated 2068 PTMC patients who underwent thyroid operation with lymph node (LN) diss...

Background: The prevalence of thyroid cancer has increased very rapidly in Korea. However, there is no data focusing on thyroid cancer mortality in Korea. In this study, we aimed to evaluate standardized thyroid cancer mortality using national data from Statistics Korea.Methods: Population and mortality data from 1985 to 2015 were obtained from Statistics Korea. Age-standardized mortality rates (ASMR) of thyroid cancer per 100 000 were calculated accordi...

Background: Anaplastic thyroid carcinoma (ATC) is the most aggressive type of thyroid cancer and has no effective therapy. Due to its dismal prognosis, it is vital to understand the genetic alterations of ATC and identify effective molecular targets. We performed targeted next-generation sequencing to investigate the mutational profile of ATC using a massive parallel sequencing approach.Methods: DNA from formalin-fixed, paraffin-embedded archival samples...

Introduction: This study aimed to examine whether altered Heart Rate Variability (HRV) could predict the risk of development of metabolic syndrome (MetSD) in Asians.Methods: We investigated health checkup records of 33 752 adults aged 20–65 years old who did health checkups and HRV measurement between April 2011 and June 2014 at Kangbuk Samsung Hospital, without MetSD, anemia, thyroid disease, malignancy, and heart disease. A 3-minute HRV recording ...

Background: Unlike excellent prognosis of classical papillary thyroid carcinoma (cPTC), certain pathological subtypes of aggressive variants of PTC (AV-PTC) are considered to have poor clinical outcome. However, the evidence of unfavorable outcome of AV-PTC is not clear because previous studies did not control other confounding factors contributed to clinical outcomes.Methods: This retrospective cohort study initially included 4339 patients with cPTC and...